Zheng Zhang


“Thiol-ene click chemistry for regenerative medicine”


Dr. Zheng Zhang is a senior scientist at Mosaic Biosciences, a start-up company focusing on thiol-ene click chemistry for regenerative medicine. Dr. Zhang has more than 15 years of experience in biomaterials, controlled drug delivery and tissue engineering. Prior to Mosaic Biosciences, Dr. Zhang was a research Assistant Professor at New Jersey Center for Biomaterials (NJCBM), Rutgers, The State University of New Jersey. Prior to NJCBM, Dr. Zhang was a University Docent at University of Twente, the Netherlands, and a visiting professor at Institute of Advanced Biomedical Engineering and Science in Japan. Dr. Zhang has serviced as leading scientist and co-P.I. in multiple NIH and DoD projects, and raised various funding from NIH, DoD, and Fortune 500 companies. Dr. Zhang has co-authored over 40 papers and book chapters; his publications were cited over 1600 times, with high-index > 20.


New advancements in therapeutic proteins, antibodies, and cells have triggered a revolution in pharma R&D and manufacturing. Mosaic Biosciences, Inc. has developed a platform thiol-ene click chemistry technology that allows for encapsulation and delivery of these therapeutics. The thiol-ene chemistry is fast and bio-orthogonal: the reaction occurs under physiological conditions, rendering bioconjugation and/or curing of formulation in just 2-3 seconds.

Mosaic Biosciences’ proprietary portfolio contain a library of synthetic polymers and various biological components, bio-orthogonal conjugation methods, and formulation techniques. This talk will cover the unique feature and advantages of thiol-ene chemistry that differ from Michael addition, the feasibility of our technology in surgical uses and in cell encapsulation, a showcase of protein encapsulation and controlled delivery, and results from in vivo studies demonstrating safety and applicability of Mosaic’s technology in wound healing.